This education program is developed and delivered for The University of Queensland, by The University of Queensland (UQ) Health Insitu. UQ Health Insitu is the lifelong learning arm of The University of Queensland Faculty of Health Sciences.
Expert presenters:
Dr Chris Davis
Dr Chris Davis is Director of Geriatric and Rehabilitation Medicine at Brisbane's Prince Charles Hospital, and medical teacher and examiner in the University of Queensland. The clinical service he directs has over 30,000 patient bed days per annum, as well as very substantial outpatient and domiciliary services. Much of the work relates to dementia care and is enhanced by strong links between Mental Health and Geriatric services.
Chris is able to draw on his local and international experience as researcher and lecturer in dementia care, as well as active ongoing involvement in helping a large number of patients and relatives affected by dementia. He has developed valuable perspectives on General Practice through his role in Co-ordinated Care and Residential Care trials, as well as regular dialogue with GP colleagues.
Associate Professor Gerard Byrne
Gerard Byrne completed his medical degree and an intercalated science degree in Sydney at the University of New South Wales and the Prince of Wales/Prince Henry Hospitals. Following an internship at the Royal Newcastle Hospital, he undertook his psychiatry training in Queensland, principally at The Prince Charles and Wolston Park Hospitals. His PhD was undertaken at the University of Queensland on the psychobiology of spousal bereavement in older men. He has been employed by the University of Queensland since 1988 and has been Head of the Department of Psychiatry since 2001.
His primary research interests include Alzheimer's disease (particularly the neuropsychiatric symptoms associated with AD), and personality, anxiety and depression in older people.
References:
Dr Chris Davis
[1] Access Economics Pty Ltd. The dementia epidemic: economic impacts and positive solutions for Australia. Report for Alzheimer’s Australia. Canberra; March 2003. Viewed on 12/07/2007, at: http://www.alzheimers.org.au/upload/EpidemicFullReportMarch2003.pdf
[2] Victorian State Government Public Health Group. Victorian burden of disease study: mortality and morbidity in 2001. Department of Human Services. June 2005. Viewed on 04/07/2007, at: http://www.health.vic.gov.au/healthstatus/downloads/bod_2001.pdf
[3] Dekeban AS, Sadowsky D. Changes in brain weight during the span of human life. Annals of Neurology 1978;4:345-356.
[4] Hedden T, Gabrieli JD. Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 2004 Feb;5(2):87-96.
[5] Raz N. Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In: Craik FIM, Salthouse TA, editors. Handbook of aging and cognition — II. Hillsdale, NJ: Erlbaum; 2000. p. 1–90.
[6] De Groot JC, De Leeuw FE, Oudkerk M, Gijn JV, Hofman A, Jolles J, et al. Cerebral white matter lesions and cognitive function: The Rotterdam scan study.
Annals of Neurology 2000;47(2):145-151.
[7] Ritchie K, Lovestone S. The dementias. Lancet 2002 Nov 30;360(9347):1759-66.
[8] Rogaeva E, Kawarai T, St George-Hyslop P. Genetic complexity of Alzheimer's disease: successes and challenges. Journal of Alzheimer's Disease 2006;9 Suppl 3:381–387.
[9] Diagnostic and statistical manual of mental disorders: DSM-IV-TR. 4th ed. Washington, DC: American Psychiatric Association; 2000.
[10] Cullen B, O'neill B, Evans JJ, Coen RF, Lawlor BA. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatry 2006;78:790-799.
[11] Folstein MF, Folstein SE, McHugh PR. ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. Psychiatr Res 1975 Nov;12(3):189-98.
[12] Brodaty H, Kemp NM, Harding L, Berman K, Huppert FA. The GPCOG: a new screening test for dementia designed for general practice. Journal of the American Geriatrics Society 2002;50(3):530.
[13] Buschke H, Kuslansky G, Katz M, Stewart WF, Sliwinski MJ, Eckholdt HM, et al. Screening for dementia with the Memory Impairment Screen. Neurology 1999 Jan;52(2):224 - 224.
[14] Brodaty H, Low L-F, Burns LGK. What Is the Best Dementia Screening Instrument for General Practitioners to Use? Am J Geriatr Psychiatry 2006 May;14:391-400.
[15] Jost BC, Grossberg GT. The evolution of psychiatric symptoms in Alzheimer's disease: a natural history study. J Am Geriatr Soc 1996 Sep;44(9):1078-81.
[16] Wang D-S, Dickson DW, Malter JS. Amyloid Degradation and Alzheimer's Disease. Journal of Biomedicine and Biotechnology. 2006. Article ID 58406. Viewed on 12/07/2007, at: http://www.hindawi.com/PDF.aspx?doi=10.1155/JBB/2006/58406
[17] Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M, et al. An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997;11 Suppl 2:S33-9.
[18] Jellinger KA. Clinicopathological analysis of dementia disorders in the elderly--an update.J Alzheimers Dis 2006;9(3 Supp l):61-70.
[19] Dubinsky RM, Stein AC, Lyons K. Practice parameter: risk of driving and Alzheimer’s disease (an evidence-based review).
Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006;54:2205-2211.
Assoc Prof Gerard Byrne
[1] Neville CC, Byrne GJA. Behaviour rating scales for older people with dementia: which is the best for use by nurses? Australasian Journal on Ageing 2001;20: 166–72.
[2] Lyketsos CG, Sheppard JE, Steinberg M, Tschanz JT, Norton MC, Steffens DC, et al. Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study. Int J Geriatr Psychiatry 2001 Nov;16(11):1043-53.
[3] Brodaty H, Draper B, Saab D, Low L, Richards V, Paton H et al. Psychosis, depression and behavioural disturbances in Sydney nursing home residents: prevalence and predictors. Int J Geriatr Psychiatry 2001 May;16(5):504-12.
[4] Byrne et al. (unpublished data).
[5] Neville, CC, Byrne GJA. Behaviour of older people admitted for residential respite care. Aust J Adv Nurs 2002 Sep-Nov;20(1):8-12.
[6] Aalten P, de Vugt ME, Jaspers N, Jolles J, Verhey FRJ. The course of neuropsychiatric symptoms in dementia. Part I: findings from the two-year longitudinal Maasbed study. Int J Geriatr Psychiatry 2005 Jun;20(6):523-30.
[7] Starkstein SE, Jorge R, Mizrahi R, Robinson RGR. The construct of minor and major depression in Alzheimer’s Disease. Am J Psychiatry 2005 Nov;162:2086-93.
[8] Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, SteffensDC, Breitner JCS. Mental and behavioral disturbances in Dementia: findings From the Cache County study on memory in ageing. Am J Psychiatry 2000 May;157:708-714.
[9] Peisah C, Snowdon J, Gorrie C, Kril J, Rodriguez M. Investigation of Alzheimer's disease-related pathology in community dwelling older subjects who committed suicide. J Affect Disord 2007 Apr;99(1-3):127-32.
[10] Yaffe K, Fox P, Newcomer R, Sands L, Lindquist K, Dane K, et al. Patient and caregiver characteristics and nursing home placement in patients with dementia. JAMA 2002;287:2090-97.
[11] Slack and Byrne (unpublished manuscript).
[12] Callahan CM, Boustani MA, Unverzagt FW, Austrom MG, Damush TM, Perkins AJ, et al. Effectiveness of collaborative care for older adults with Alzheimer’s disease in primary care: a randomised controlled trial. JAMA 2006;295:2148-57.
[13] Belle SH, Burgio L, Burns R, Coon D, Czaja SJ, Gallagher D, et al. Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: a randomised controlled trial. Ann Intern Med 2006;145(10):727-38.
[14] Parahoo K, Whall AL, Colling K, Nusbaum D, et al. Expert nurses’ use of implicit memory in the care of patients with Alzheimer’s disease. J Adv Nurs 2006;54(5):563-71.
[15] Opie J, Rosewarne R, O’Connor DW. The efficacy of psychosocial approaches to behaviour disorders in dementia: a systematic literature review. Aust NZ J Psychiatry 1999 Dec;33(6):789-99.
[16] Bird M, Llewellyn-Jones R, Smithers H, Korten AE. Psychosocial approaches to challenging behaviour in dementia: a controlled trial. Canberra: Commonwealth Department of Health and Ageing; 2002.
[17] Turner S. Behavioural symptoms of dementia in residential settings: a selective review of non-pharmacological interventions.
Aging Ment Health. 2005 Mar;9(2):93-104.
[18] Lyketsos CG, DelCampo L, Steinberg M, Miles Q, Steele CD, Munro C, et al. Treating depression in Alzheimer Disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Arch Gen Psychiatry 2003;60(7):737-46.
[19] Tariot PN, Erb R, Podgorski CA, Cox C, Patel S, Jakimovich L, et al. Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am J Psychiatry 1998 Jan;155:54-61.
[20] Olin JT, Fox LS, Pawluczyk S, Taggart NA, Schneider LS. A pilot randomised trial of carbamazepine for behavioral symptoms in treatment-resistant outpatients with Alzheimer Disease. Am J Geriatr Psychiatry 2001 Nov;9:400-05.
[21] Porsteinsson AP, Tariot PN, Erb R, Cox C, Smith E, Jakimovich L. Placebo-controlled study of Divalproex sodium for agitation in Dementia. Am J Geriatr Psychiatry 2001 Feb;9:58-66.
[22] Lonergan ET, Luxenberg J. Valproate preparations for agitation in dementia. Cochrane Database Syst Rev 2004;(2):CD003945.pub2.
[23] Tariot PN, Raman R, Jakimovich L, Schneider L, Porsteinsson A, Thomas R. Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: a randomized, controlled trial. Am J Geriatr Psychiatry 2005 Nov;13:942-49.
[24] Hermann N, Lanctôt, KL, Rothenburg LS, Ervavec G. A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease. Dement Geriatr Cogn Disord 2007;23:116-19.
[25] Ballard C, Waite J. The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease. Cochrane Database Syst Rev 2006 Jan 25;(1):CD003476.
[26] Brodaty H, Ames D, Snowdon J, et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry 2003;64:134-43.
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